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Safety in Lactation: Antidepressants

21 October 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Monamine-oxidase inhibitors (MAOIs) Due to the…

What is serotonin syndrome and which medicines cause it?

22 May 2020This Medicines Q&A outlines the causes and symptoms of serotonin syndrome and provides examples of medicines with the potential to cause serotonin syndrome.  

How do you switch between tricyclic, SSRI and related antidepressants?

21 October 2019This updated Medicines Q&A provides advice on the risks and suggested strategies for switching between tricyclic (TCA), selective serotonin reuptake inhibitors (SSRI) and related antidepressants.…

Is there a lactose-free antidepressant?

24 September 2019This Medicine Q&A lists currently available lactose-free antidepressant preparations. There is a lactose-free preparation available for all antidepressants except for clomipramine, doxepin, isocarboxazid, moclobemide, nortriptyline…

If antidepressant-induced hyponatraemia has been diagnosed, how should the depression be treated?

10 June 2019This Medicines Q&A evaluates the evidence available on the management of depression in patients with antidepressant-induced hyponatraemia. Summary Most antidepressants are associated with hyponatraemia, with…
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Medicine Compliance Aid Stability

genericTeva UK Ltd

Teva UK Ltd
generic
Tablets s/c 75mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Protect from light
Protect from moisture
Protect from moisture and light.
26 October 2015

ProthiadenTeofarma

Teofarma
Prothiaden
Capsules 25mg, Tablets s/c 75mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Protect from light
Protect from moisture
Protect from moisture. Protect from light.
26 October 2015

Lactation Safety Information

Yes
Imipramine, Nortriptyline
Synonym: Dothiepin
Moderate level of evidence of safety in breastfeeding indicate small amounts in breast milk
Long half-life of active metabolites increases risk of accumulation in breastfed infants
Monitor infants for drowsiness, poor feeding and irritability/behavioural effects, although no adverse effects have been reported in breastfed infants
30 July 2020