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Safety in Lactation: Anthracyclines and other cytotoxic antibiotics

18 September 2020Anthracycline and related cytostatic antibiotics, whether used as monotherapy or in combination with other antineoplastics, are contra-indicated in breastfeeding because of their cytotoxic action on…
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Refrigerated Storage

Doxorubicin Medac GmbH

Medac GmbH
Doxorubicin
2mg/ml solution for injection

In the event of an inadvertent temperature excursion the following data may be used:
Short term temperature excursions between 0-2°C are not expected to negatively impact the product.

In-house stability data supports a temperature excursion of up to a maximum temperature of 25°C for 12 hours. The product can be returned to the fridge and no change in expiry date is required.
If the temperature excursion exceeds 12 hours above 8°C reduce the expiry date to 14 days from the date of the temperature excursion.

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

3 February 2022
London MI Service

Doxorubicin Pfizer

Pfizer
Doxorubicin
Solution for injection, 2mg/mL

Contact Pfizer in all cases where a deviation from the recommended storage conditions has occurred. Refer to the electronic medicines compendium (eMC) at https://www.medicines.org.uk for company contact details.

10 March 2022
London MI Service

Lactation Safety Information

No
Serious adverse effects reported in adults
Very limited evidence suggests that, although low levels anticipated in milk due to the drug’s properties, the prolonged persistence of an active metabolite means that the potential risk to the infant outweighs benefits of breastfeeding
5 August 2020