In the event of an inadvertent temperature excursion the following data may be used:

From the time the durvalumab vial arrives at the healthcare professional’s facility/pharmacy until it is ready for use, a single storage deviation of up to 24 hours duration at temperatures from 0°C to <2°C, >8°C to 25°C, or >25°C to 40°C is within stability limits for durvalumab.

If the product is stored outside the recommended temperature range beyond the 24-hour duration, durvalumab should be discarded.

In the event that a temperature storage deviation is identified, even if the deviation is well within the time and temperature ranges indicated directly above, the product should be returned immediately to the recommended storage condition of 2°C to 8°C and used as soon as it is feasible.

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk*