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Shortage of Instanyl 100 and 200micrograms/dose nasal spray (immediate-release fentanyl citrate)

3 February 2021Takeda UK have indicated that they are out of stock of Instanyl 100 and 200micrograms/dose nasal spray which is licensed for the treatment of breakthrough…

Safety in Lactation: Opioid analgesics

21 October 2020The evidence relating to the safe use of opioid analgesics in breastfeeding mothers is very variable between individual drugs. This group of drugs presents a…

Safety in Lactation: Sedative and analgesic peri-operative drugs

25 September 2020Benzodiazepines are used for premedication and for conscious sedation during surgery. Following short–term therapy (1-2 doses) for these indications, it is considered that breastfeeding can…

What is serotonin syndrome and which medicines cause it?

22 May 2020This Medicines Q&A outlines the causes and symptoms of serotonin syndrome and provides examples of medicines with the potential to cause serotonin syndrome.  

What naloxone doses should be used in adults to urgently reverse the effects of opioids?

19 December 2019The opioid antagonist, naloxone, is a highly effective antidote the use of which is potentially life-saving. The drug has a role in a wide range…
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Medicine Compliance Aid Stability

AbstralProStrakan Pharmaceuticals

ProStrakan Pharmaceuticals
Abstral
Tablets sublingual - various strengths
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Designed for sublingual administration
11 May 2015

EffentoraCephalon UK Ltd

Cephalon UK Ltd
Effentora
Buccal tablets - various strengths
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Unsuitable for MCA as hygroscopic buccal tablets designed for sublingual administration.
11 May 2015

ActiqFlynn Pharma Ltd

Flynn Pharma Ltd
Actiq
Lozenge (buccal) - various strengths
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Unsuitable for MCA as hygroscopic buccal tablets, which should not be swallowed.
11 May 2015

Lactation Safety Information

Tablets / Lozenges / Nasal spray / Transdermal for pain

Tablets / Lozenges / Nasal spray / Transdermal
for pain
Small amounts in breast milk probably due to short half-life
Although adverse effects in infant are not likely, infant monitoring advised, especially in young infants (see summary)
22 September 2020

Injection for use during surgery

Injection
for use during surgery
Yes
Small amounts in breast milk probably due to short half-life
22 September 2020