Fluorouracil

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Safety in Lactation: Antimetabolites

23 September 2020Antineoplastic antimetabolites, whether used as monotherapy or in combination with other antineoplastics, are contra-indicated in breastfeeding (except where indicated below) because of their effects on…

Fluorouracil: Cytotoxic Drug Stability Monograph

1 September 2020Stability information is essential for the safe aseptic preparation of fluorouracil
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Lactation Safety Information

Parenteral

Parenteral
Very limited published evidence indicates negligible levels in breast milk
If used as monotherapy do not resume breastfeeding until at least 24 hours after a dose, and monitor infant’s blood count
Discontinue breastfeeding if used in combination with other antineoplastics
3 August 2020

Topical

Topical
Imiquimod
Avoid use on large areas of skin and on the nipple and areola area
Avoid contact of the breastfeeding infant with treated areas
30 October 2020