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Articles

Safety in Lactation: Drugs affecting gonadotrophins

17 September 2020The most common use of these drugs in women is for endometriosis, the symptoms of which may be supressed during pregnancy and while breastfeeding. The…
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Lactation Safety Information

Buserelin
No published evidence of safety
Negligible levels anticipated in milk, due to drug’s properties, with subsequent minimal absorption from the infant’s GI tract
17 September 2020

New Medicines

Zoladex LAOestrogen-receptor positive early and advanced breast cancer in pre- and peri-menopausal women - LA formulation

Information

Zoladex LA
Licence extension / variation
AstraZeneca
AstraZeneca

Development and Regulatory status

Launched
None
None
December 2021
Dec 21MHRA approves a new indication for the management of oestrogen-receptor positive early and advanced breast cancer in pre and peri menopausal women [1].

Category

A gonadotropin releasing hormone analogue which down-regulates pituitary-ovarian gonadal axis resulting in suppression of ovarian steroidogenesis and a decline in oestrogen levels. 10.8mg implant.
Breast cancer is the most common cancer in the UK, accounting for 15% of all new cancer cases in 2017. In patients with hormone receptor-positive disease, who represent approximately 75% of patients with breast cancer, hormone therapy is an effective treatment option.
Oestrogen-receptor positive early and advanced breast cancer in pre- and peri-menopausal women - LA formulation
Intramuscular