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Articles

Safety in Lactation: Drugs used for allergic conditions

22 May 2017Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Antihistamines Non-sedating antihistamines (NSA) preferred over…
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Medicine Compliance Aid Stability

GrazaxALK-Abello Ltd

ALK-Abello Ltd
Grazax
Tablet 75,000units
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Very sensitive to moisture.
29 September 2015

Lactation Safety Information

Yes
-
No published evidence of safety
Components of the allergen unlikely to enter breast milk
No adverse effects reported in breastfed infants
22 May 2017

New Medicines

Moderate to severe grass pollen-induced seasonal allergic rhinoconjunctivitis in adults

Information

New molecular entity
ASIT Biotech
ASIT Biotech

Development and Regulatory status

None
Phase III Clinical Trials
None

Category

A peptide hydrolysate from Lolium perenne, consisting of highly purified natural allergen fragments. The ASIT+ allergen fragments rapidly triggers a protective immune response without need of an adjuvant. Given as 4 doses over 3 weeks.
Allergic rhinitis is a common problem, affecting over 20% of the UK population. Grass pollens usually cause symptoms from late spring to early summer. Main lines of treatment are education, allergy avoidance, antihistamines and topical steroids [1]. NHS England has estimated that ~20,000 people in England require referral to a specialist centre for severe allergy, with half of those receiving specialist interventions such as immunotherapy or investigation for drug allergy [2].
Moderate to severe grass pollen-induced seasonal allergic rhinoconjunctivitis in adults
Subcutaneous injection