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RMOC Best Value Biologic – Insulin Glargine Toolkit, consultation closed

26 November 2020A draft toolkit has been produced on Best value biologic – insulin glargine, on behalf of the RMOC system. Insulin glargine is the first medicine managed…

Safety in Lactation: Insulins

23 September 2020Exogenous insulin is excreted into breast milk, including that from insulin analogues. Insulin in breast milk is thought to be necessary for intestinal maturation of…

Insulin preparations: RMOC recommendations of safety considerations for formulary decision making

22 June 2018At its meeting on 18th April 2018 the Regional Medicines Optimisation Committee (RMOC) (Midlands and East) reviewed issues pertaining to safety considerations when adopting any…
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Refrigerated Storage

LantusSanofi

Sanofi
Lantus
Solution for injection. 100 units/mL. Vials, cartridges and pre-filled pen (SoloStar)

In the event of an inadvertent temperature excursion the following data may be used:

Vials
Unopened vials are not to be stored above 8°C. Storage of unopened vials or in-use vials above the recommended 8°C reduces shelf life to 28 days. The vial can be stored back in the refrigerator (2-8°C) or at temperatures not exceeding 25°C for 5 ml vials and 30°C for 10ml vials.

Cartridges
If unopened cartridges are stored above 8°C they have a reduced shelf life of 28 days and may be stored back in the refrigerator (2-8°C) or at room temperature below 30°C. In-use cartridges in the pen device should be stored at room temperature not exceeding 30°C and must be discarded 28 days after opening.

SoloStar
If unused SoloStar pens are stored between 8°C to 30°C they have a reduced shelf life of 28 days. After first use, a SoloStar pen should continue to be stored at room temperature not exceeding 30°C for a maximum of 28 days.

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

If exposed to temperatures as described above, reduce the expiry date to 28 days from the date of excursion.
12 October 2020
London MI Service

ToujeoSanofi

Sanofi
Toujeo
Injection, 300 units/ml, pre-filled disposable injection

In the event of an inadvertent temperature excursion the following data may be used:
Shelf life after first use of the pen
The medicinal product may be stored for a maximum of 6 weeks below 30°C and away from direct heat or direct light. Pens in use must not be stored in the refrigerator.

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

6 weeks when exposed to conditions described above
Store the pen outside of the fridge when exposed to conditions described above

Do not freeze.

12 October 2020
London MI Service

AbasaglarEli Lilly

Eli Lilly
Abasaglar
100 units/ml solution for injection in cartridge and pre-filled pen

In the event of an inadvertent temperature excursion the following data may be used:
The medicinal product may be stored for a maximum of 28 days up to 30°C. Do not return to the fridge.
Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

Contact Eli Lilly in all other cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company details.

Reduce expiry to 28 days if exposed to the conditions above
Keep the product outside of the fridge if exposed to the conditions above
29 September 2021
London MI Service

Lactation Safety Information

Yes
Likely to be degraded in infant's GI tract
Long-acting recombinant human insulin
16 September 2020