Safety in Lactation: Drugs for cytotoxic-induced side-effects

25 September 2020As these drugs are used to prevent, or treat, specific adverse effects of certain antineoplastic agents or radiotherapy, the risk of their use in breastfeeding…
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Refrigerated Storage

IsovorinPfizer limited

Pfizer limited
Solution for Injection 10 mg/mL

Contact Pfizer in all cases where a deviation from the recommended storage conditions has occurred.

Refer to the current BNF for company contact details.

24 July 2020
London MI Service

Levofolinic acidMedac GmbH

Medac GmbH
Levofolinic acid
50mg/ml, 200mg/4ml

In the event of an inadvertent temperature excursion the following data may be used:

The product can be stored at room temperature (max 25°C) for 72 hours without detriment to the product. Extended stability data are available on request from the manufacturer.

Please also refer to the manufacturer’s product literature for recommended storage information at

No - the expiry date does not have to be altered providing the product is returned to the fridge within 72 hours at temperatures not exceeding 25°C.
Yes - under the conditions described above
15 May 2020
London MI Service

Lactation Safety Information

Calcium/ disodium levofolinate

Calcium/ disodium levofolinate
No published evidence of safety
Isomer of folinic acid used to reduce toxicity of methotrexate and as an adjunct to fluorouracil
Folic acid is a normal component of breast milk
16 September 2020