Linaclotide

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Safety in lactation: Laxatives

25 September 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Bulk-forming laxatives Bulk-forming laxatives are not…

Medicines that are considered safe for use in the acute porphyrias

29 May 2020The UK Porphyria Medicines Information Service (UKPMIS) and Cardiff Porphyria Service produce a list of medicines that are considered to be safe for use in…
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Lactation Safety Information

Yes
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Guanylate cyclase-C receptor agonist used for moderate to severe irritable bowel syndrome with constipation
Minimal absorption of linaclotide and active metabolite from mother’s GI tract
No published evidence of safety
Broken down to peptides and amino acids in the mother’s GI tract, which are not known to pose a risk to the breastfed infant
26 July 2016