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Equivalent doses of oral benzodiazepines

6 July 2021Benzodiazepines are the most commonly used anxiolytics and hypnotics. There are major differences in potency between different benzodiazepines and this difference in potency is important…

Safety in Lactation: Drugs used in status epilepticus

5 November 2020Choice of treatment will be influenced by the clinical situation. The evidence for these drugs in breastfeeding is based on their longer-term use rather than…

Safety in Lactation: Anxiolytics.

21 October 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Use of anxiolytics in breastfeeding mothers…

Safety in Lactation: Sedative and analgesic peri-operative drugs

25 September 2020Benzodiazepines are used for premedication and for conscious sedation during surgery. Following short–term therapy (1-2 doses) for these indications, it is considered that breastfeeding can…

Lorazepam products: ambient stability during COVID-19

30 April 2020Lorazepam 4mg/1ml solution for injection Ativan 4mg/1ml solution for injection ampoules (Pfizer Ltd) Can be stored at room temperature for up to 24 hours ahead…
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Refrigerated Storage

AtivanPfizer Ltd

Pfizer Ltd
Ativan
Injection, 4mg/mL

Contact Pfizer Limited in all cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

During the COVID emergency it is especially important to conserve medicine stocks and to minimise avoidable waste. If ANY critical medicines are subject to temperature excursions during this time and your pharmacy team are in any doubt about whether or not it is safe to use them, you are strongly advised to contact your Regional QA Pharmacist to agree the most appropriate course of action.

5 June 2020
London MI Service

CarpujectPfizer Ltd

Pfizer Ltd
Carpuject
Injection (single cartridges), 2mg/mL

In the event of an inadvertent temperature excursion the following data from the manufacturer can be considered:

An unpublished in-house stability study suggests that product quality may be maintained when exposed to temperatures not exceeding 25°C  for up to a period of 1 month. 

However it is important to note that it is not possible to verify these data and healthcare professionals need to make their own practical decisions about its use in each situation, seeking input from colleagues with quality assurance expertise if needed.

The manufacturer (Pfizer Limited) can also be contacted for further clarification in all cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.

Information not provided by manufacturer
Yes

During the COVID emergency it is especially important to conserve medicine stocks and to minimise avoidable waste. If ANY critical medicines are subject to temperature excursions during this time and your pharmacy team are in any doubt about whether or not it is safe to use them, you are strongly advised to contact your Regional QA Pharmacist to agree the most appropriate course of action.

5 June 2020
London MI Service

Medicine Compliance Aid Stability

genericGenus Pharmaceuticals

Genus Pharmaceuticals
generic
Tablets 1mg, 2.5mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Protect from light
Protect from moisture
Protect from moisture. Protect from light.
1 October 2015

Lactation Safety Information

For anxiety

For anxiety
Oxazepam
Shorter-acting agent
Limited published evidence of safety
Small amounts in breast milk
Monitor the infant closely for drowsiness, poor feeding and adequate weight gain
11 September 2020

Parenteral for status epilepticus

Parenteral
for status epilepticus
Clonazepam
Limited published evidence of safety
Small amounts in breast milk
Short-term therapy (1-2 doses) considered not to pose a risk to the infant
11 September 2020

For premedication / conscious sedation

For premedication / conscious sedation
Yes
Limited published evidence of safety
Small amounts in breast milk
Shorter-acting benzodiazepine
11 September 2020