Choosing equivalent doses of oral benzodiazepines

25 January 2022Approximate equivalent doses of oral benzodiazepines to diazepam. Doses are not exact because of differences between the medicines.

Safety in Lactation: Drugs used in status epilepticus

5 November 2020Choice of treatment will be influenced by the clinical situation. The evidence for these drugs in breastfeeding is based on their longer-term use rather than…

Safety in Lactation: Anxiolytics.

21 October 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Use of anxiolytics in breastfeeding mothers…

Safety in Lactation: Sedative and analgesic peri-operative drugs

25 September 2020Benzodiazepines are used for premedication and for conscious sedation during surgery. Following short–term therapy (1-2 doses) for these indications, it is considered that breastfeeding can…
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Refrigerated Storage

Lorazepam Macure Macure Pharma

Macure Pharma
Lorazepam Macure
4 mg/mL solution for injection

In the event of an inadvertent temperature excursion the following data may be used:
The product is stable when exposed to the following conditions:

  • 48 hours at temperatures up to 25°C.
  • 3 repeated excursions of 24 hours at 25°C.
  • 7 days at freezing temperatures.

The product can be returned to the fridge and no change in expiry date is required if exposed to the conditions above.

Please also refer to the manufacturer’s product literature for recommended storage information at

17 August 2022
London MI Service

Lactation Safety Information

For anxiety

For anxiety
Shorter-acting agent
Limited published evidence of safety
Small amounts in breast milk
Monitor the infant closely for drowsiness, poor feeding and adequate weight gain
11 September 2020

Parenteral for status epilepticus

for status epilepticus
Limited published evidence of safety
Small amounts in breast milk
Short-term therapy (1-2 doses) considered not to pose a risk to the infant
11 September 2020

For premedication / conscious sedation

For premedication / conscious sedation
Limited published evidence of safety
Small amounts in breast milk
Shorter-acting benzodiazepine
11 September 2020