Mercaptopurine

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Switching between liquid and tablet/capsule formulations – Which medicines require extra care?

19 July 2021For a small number of medicines, there are differences in equivalent doses of oral formulations of the same medicine. This needs to be considered when…

Safety in Lactation: Antimetabolites

23 September 2020Antineoplastic antimetabolites, whether used as monotherapy or in combination with other antineoplastics, are contra-indicated in breastfeeding (except where indicated below) because of their effects on…

Safety in lactation: Drugs for chronic bowel disorders

21 September 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Aminosalicylates for chronic bowel disorders Mesalazine…
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Lactation Safety Information

As an antineoplastic antimetabolite

As an antineoplastic antimetabolite
Active metabolite of azathioprine
Limited evidence for safety of mercaptopurine, but moderate level of evidence for azathioprine
If used, monitor infant’s blood count and liver function and for signs of immunosuppression
Discontinue breastfeeding if used in combination with other antineoplastics
24 September 2020

For inflammatory bowel disease

For inflammatory bowel disease
See summary
Active metabolite of azathioprine
Limited evidence for safety of mercaptopurine, but moderate level of evidence for azathioprine
If used, monitor infant’s blood count and liver function and for signs of immunosuppression
24 September 2020