Safety in Lactation: Opioid dependence

27 October 2020An assessment of the risks associated with breastfeeding by an opioid-dependent mother, in terms of sustaining successful breastfeeding and possible exposure of the infant to…

Safety in Lactation: Opioid analgesics

21 October 2020The evidence relating to the safe use of opioid analgesics in breastfeeding mothers is very variable between individual drugs. This group of drugs presents a…

What is serotonin syndrome and which medicines cause it?

22 May 2020This Medicines Q&A outlines the causes and symptoms of serotonin syndrome and provides examples of medicines with the potential to cause serotonin syndrome.  

What are the clinically significant drug interactions with tobacco smoking?

23 March 2020This Medicines Q&A summarises those drug interactions with tobacco smoking that are considered to be most clinically important. Most interactions between drugs and tobacco smoking…

What naloxone doses should be used in adults to urgently reverse the effects of opioids?

19 December 2019The opioid antagonist, naloxone, is a highly effective antidote the use of which is potentially life-saving. The drug has a role in a wide range…
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Medicine Compliance Aid Stability


Tablets 5mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Protect from light
Protect from moisture
Keep dry and protect from light.
11 May 2015

Lactation Safety Information

For pain

For pain
Morphine or other appropriate analgesic
Small amounts in breast milk
Infant monitoring advised, especially in young infants (see summary)
Although considered compatible with breastfeeding, the use of methadone is limited mainly to treatment of opioid dependence. See more extensive comments under this use of methadone – 4.10.3
29 July 2020

For opioid dependence

For opioid dependence
Small amounts in breast milk
Moderate level of evidence and experience of use in breastfeeding
Infants exposed to methadone in utero should breastfeed normally after delivery if mother is stable
Methadone in breast milk may decrease withdrawal symptoms if infant exposed in utero, but will be insufficient to allow dose reduction of any treatment of the infant
Infants may experience withdrawal symptoms if the mother has an abrupt withdrawal of methadone or if the infant is weaned abruptly
Adverse effects more likely to occur in infants not exposed in utero or when the mother is receiving a high maintenance dose
Infant monitoring advised, especially in young infants (see summary)
29 July 2020