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Lactation Safety Information

No published evidence of safety
Monitor infant’s blood pressure
4 August 2020

New Medicines

BramoxSevere orthostatic hypotension due to autonomic dysfunction - new 10mg tablet formulation


New formulation
Brancaster Pharma
Not Known

Development and Regulatory status

Approved (Licensed)
July 2021
Jul 21Bramox is licensed in the UK for use in adults for the treatment of severe orthostatic hypotension due to autonomic dysfunction when corrective factors have been ruled out and other forms of treatment are inadequate [3].
Jul 21Available in UK. Price = 1x100 10mg Tablets = £120.50 [3,4,5].
Jan 21New formulation approved in the UK. Also approved in the EU [2].


Pro-drug of the pharmacologically active constituent desglymidodrine. Desglymidodrine is a sympathomimetic agent with a direct and selective effect on the peripheral α1-adrenergic receptors. Taken three times daily, up to 30mg/day.
Prevalence is age-dependent, ranging from 5% in patients under 50 years of age to 30% in those over 70 years of age. Orthostatic hypotension frequently contributes to falls and syncopal episodes. In Parkinsons disease the prevalence may be as high as 60%. The majority of patients with orthostatic hypotension are asymptomatic or have a few nonspecific symptoms [1].
Severe orthostatic hypotension due to autonomic dysfunction - new 10mg tablet formulation