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Articles

Choosing a suitable antidepressant for people with coronary heart disease (CHD)

2 July 2021Prescribers may need to choose a safe antidepressant in people with CHD. We guide on available options. We do not cover management of complex depression.

Safety in Lactation: Antidepressants

21 October 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Monamine-oxidase inhibitors (MAOIs) Due to the…

What is serotonin syndrome and which medicines cause it?

22 May 2020This Medicines Q&A outlines the causes and symptoms of serotonin syndrome and provides examples of medicines with the potential to cause serotonin syndrome.  

How do you switch between tricyclic, SSRI and related antidepressants?

21 October 2019This updated Medicines Q&A provides advice on the risks and suggested strategies for switching between tricyclic (TCA), selective serotonin reuptake inhibitors (SSRI) and related antidepressants.…

If antidepressant-induced hyponatraemia has been diagnosed, how should the depression be treated?

10 June 2019This Medicines Q&A evaluates the evidence available on the management of depression in patients with antidepressant-induced hyponatraemia. Summary Most antidepressants are associated with hyponatraemia, with…
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Medicine Compliance Aid Stability

genericActavis UK Ltd

Actavis UK Ltd
generic
tablets 15mg, 45mg
A2 · Amber 2No stability data is available, the manufacturer does not, or cannot recommend use in CAs but there are no theoretical concerns with the product.
No special precautions for storage
No special precautions for storage
14 October 2015

genericActavis UK Ltd

Actavis UK Ltd
generic
Tablets 30mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Protect from light
Protect from light.
14 October 2015

genericActavis UK Ltd

Actavis UK Ltd
generic
Tablets orodispersible 15mg, 30mg, 45mg
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Orodispersible tablet.
14 October 2015

Lactation Safety Information

TCA: imipramine/nortriptyline SSRI: paroxetine/sertraline
Limited published evidence of safety
Small amounts in breast milk but long half-life increases risk of accumulation in breastfed infants
Monitor infant for drowsiness, poor feeding, irritability/behavioural effects
22 January 2020