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414804006
Refrigerated Storage
TysabriBiogen Idec Ltd
Biogen Idec Ltd
Tysabri
150 mg solution for injection in pre-filled syringe
In the event of an inadvertent temperature excursion the following data may be used:
The pre-filled syringes (PFS) can be kept in their original packaging for up to 24 hours at room temperature (up to 25° C).
Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk
Contact Biogen Idec Ltd for additional information in cases where a deviation from the recommended storage conditions has occurred.
22 May 2023
London MI service
Tysabri Biogen Idec Ltd
Biogen Idec Ltd
Tysabri
300mg Concentrate for solution for infusion
Contact Biogen Idec Ltd in all cases where a deviation from the recommended storage conditions has occurred.
Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk
22 May 2023
London MI service
Lactation Safety Information
No alternative for stage of multiple sclerosis for which used
Limited published evidence shows variable levels in breast milk, ranging from undetectable to moderate.
The long half-life increases the risk of accumulation
Natalizumab is a very large protein molecule which is likely to be degraded in the infant’s gastro-intestinal tract. Very limited published evidence shows infant serum levels are undetectable.
As a precaution, the infant should be monitored for signs of infection, changes in feeding and poor weight gain.
Breastfeeding appears to have beneficial effects to a mother with multiple sclerosis
15 March 2022