NorursoPrimary sclerosing cholangitis in patients aged 16 years and older
New molecular entity
Development and Regulatory status
Phase III Clinical Trials
Homologue of ursodeoxycholic acid, thought to repeatedly be secreted by the liver cells, partially re-absorbed by the bile duct cells, and taken up by the liver cells again. Repetition of this cycle prevents build-up of bile acids.
PSC is a rare disease with a prevalence of 0.2-16 per 100,000. PSC commonly affects males with a median age at diagnosis of 35 years. PSC accounts for 10% of all UK liver transplants .
Primary sclerosing cholangitis in patients aged 16 years and older