Monoclonal antibody that attaches to CD20 on B cells
Lupus nephritis is a complication of systemic lupus erythematosus, an autoimmune disease. Up to 60 percent of those with SLE will develop lupus nephritis, and up to 25 percent develop end-stage renal disease . Lupus affects about 1 in 1,000 people in the UK. It is about six times more common in women than in men and more common in those of Caribbean, Chinese or Asian descent .
Recombinant monoclonal humanised and glycoengineered Type II anti-CD20 antibody of the IgG1 isotype
In membranous nephropathy, widespread thickening of the glomerular basement membrane occurs. It is a relatively common cause of nephrotic syndrome in adults. It progresses to end-stage kidney disease in 30-50% of patients. The remainder with idiopathic membranous nephropathy has a complete or partial spontaneous remission of nephrotic syndrome with stable renal function . It has an estimated incidence of 8-10 cases per 1 million .