Pfizer reported achievement of proof-of-concept for PF-06482077. Results from the PII trial demonstrated that the vaccine candidate was safe and well-tolerated and induced functional immune responses that could kill all twenty serotypes. Pfizer is currently planning PIII program 
PIII study (NCT03760146) results, which evaluated the safety and immunogenicity of its 20-valent pneumococcal conjugate vaccine (20vPnC) candidate in adults 18 years of age or older not previously vaccinated against pneumococcal disease. The primary immunogenicity objectives of non-inferiority was met for 19 of the the 20 serotypes in adults 60 years of age and older at one month after vaccination. The other serotype missed non-inferiority by a small margin. Data are expected to meet licensure criteria and license is expected late 2020 .
Pfizer announce positive preliminary from PII B7471003 study (NCT03512288) to assess safety and immunogenicity of 20-valent pneumococcal conjugate vaccine (20vPnC) for the prevention of invasive disease and otitis media caused by Streptococcus pneumoniae serotypes in healthy infants. The initial three doses of 20vPnC were found to have an overall safety profile similar to Prevnar 13. These data will be published once safety and immunogenicity data have been analysed following the completion of the four-dose regimen.
Pfizer report robust immunogenic responses for all 20 vaccine serotypes in the 20vPnC group of PII study. Injection site reactions (redness, swelling or pain) and systemic event rates were similar after vaccination with 20vPnC or Prevnar 13 
Pfizer announces 20vPnC includes 13 serotypes contained in Prevnar 13 (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) plus 7 additional serotypes (8, 10A, 11A, 12F, 15BC, 22F and 33F). The 7 new serotypes are global causes of invasive pneumococcal disease; 6 serotypes (8, 10A, 11A, 15BC, 22F and 33F) are associated with high case-fatality rates; 4 serotypes (11A, 15B/C, 22F and 33F) with antibiotic resistance, and/or meningitis (10A, 15B/C, 22F and 33F). Together, all 20 serotypes included are responsible for the majority of currently circulating pneumococcal disease in adults .
Pfizer initiates PIII trials (NCT03828617, NCT03835975 and NCT03760146) evaluating 20vPnC in adults. Combined, these three trials will enroll more than 6,000 adult subjects, including populations of vaccine-naïve adults and adults with prior pneumococcal vaccination
PIII trial announced |(NCT03760146) that will enroll around 3,880 adults ≥60 years old to compare immune responses after 20vPnC administration with 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccines .