Potassium bicarbonate + potassium citrate

Unassigned

New Medicines

Distal renal tubular acidosis (dRTA)

Information

New formulation
Advicenne
Advicenne

Development and Regulatory status

Phase III Clinical Trials
Phase III Clinical Trials
Phase III Clinical Trials
Yes

Category

Fixed dose combination of potassium bicarbonate and potassium citrate, in the form of prolonged-release coated granule (micro-tablets) for a 12-hour absorption.
dRTA is a disorder of impaired net acid secretion by the distal tubule characterized by hyperchloremic metabolic acidosis. The classic form is often associated with hypokalemia whereas other forms of acquired dRTA may be associated with hypokalemia, hyperkalemia or normokalemia. All forms of dRTA are chronic and may have significant effects on growth and development, but renal failure is uncommon. Prevalence of dRTA is unknown but is often underreported [1].
Distal renal tubular acidosis (dRTA)
Oral