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Safety in Lactation: Neuromuscular blocking drugs

23 September 2020Neuromuscular blocking drugs are used to induce muscle relaxation prior to surgery. With the exception of suxamethonium, they are all nearly completely ionised at physiological…
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Refrigerated Storage

RocuroniumAS Kalceks

AS Kalceks
Rocuronium
Solution for injection/infusion 10mg/mL

In the event of an inadvertent temperature excursion the following data may be used:
Rocuronium may be stored outside of the refrigerator at a temperature of up to 25°C for a maximum of 12 weeks, after which it should be discarded. The product should not be placed back into the refrigerator, once it has been kept outside.
Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

Reduce expiry to 12 weeks. The new expiry date should not exceed the labelled shelf life of the product.
No, if exposed to the conditions above
30 September 2022
London MI Service

RocuroniumBowmed Ibisqus

Bowmed Ibisqus
Rocuronium
Solution for injection/infusion 10mg/mL (ampoules and vials)

In the event of an inadvertent temperature excursion the following data may be used:
Rocuronium may be stored outside of the refrigerator at a temperature of up to 25°C for a maximum 12 weeks after which it should be discarded. The ampoule/vial should not be placed back into the refrigerator, once it has been kept outside.
For shorter excursions, the product can be stored up to 25°C for up to 15 days and then returned to the fridge.
Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

See above
3 October 2022
London MI Service

RocuroniumFresenius Kabi

Fresenius Kabi
Rocuronium
Solution for injection/infusion 10mg/mL

In the event of an inadvertent temperature excursion the following data may be used:
Rocuronium may be stored outside of the refrigerator at a temperature of up to 30°C for a maximum of 12 weeks, after which it should be discarded. The product should not be placed back into the refrigerator, once it has been kept outside.

Please also refer to the manufacturer’s product literature for recommended storage information at https://products.mhra.gov.uk/.

Reduce expiry to 12 weeks. The new expiry date should not exceed the labelled shelf life of the product.
No, if exposed to the conditions above
30 September 2022
London MI Service

RocuroniumHameln Pharma Ltd

Hameln Pharma Ltd
Rocuronium
Solution for injection/infusion 10mg/mL

In the event of an inadvertent temperature excursion the following data may be used:
Rocuronium may be stored outside of the refrigerator at a temperature of up to 30°C for a maximum 3 months, after which it should be discarded. The product should not be placed back into the refrigerator, once it has been kept outside.

Reduce expiry to 3 months. The new expiry date should not exceed the labelled shelf life of the product.
No, if exposed to the conditions above
12 October 2021
London MI Service

EsmeronMerck Sharp & Dohme Limited 

Merck Sharp & Dohme Limited 
Esmeron
Solution for injection/infusion 10mg/mL

In the event of an inadvertent temperature excursion the following data may be used:
Rocuronium can be stored outside of the refrigerator at a temperature of up to 30°C for a maximum of 12 weeks after which it should be discarded. The product can be stored either in the fridge (2-8°C) or outside of the fridge (<30°C). The storage period must not exceed the labelled shelf life.
Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

23 February 2022
London MI Service

Lactation Safety Information

Yes
No published evidence of safety
Negligible levels anticipated in milk due to the drug’s properties
18 September 2020