SHP655

Unassigned

New Medicines

Congenital thrombotic thrombocytopenic purpura (cTTP)

Information

New molecular entity
Shire
Shire

Development and Regulatory status

Phase III Clinical Trials
Phase I Clinical Trials
Phase I Clinical Trials
Yes
Yes

Category

A disintegrin and metalloprotease with thrombospondin type-1 motifs 13
TTP is rare, with a reported incidence of 6 per 1,000,000 per year in the UK. It is most common in adults, although it has been reported in neonates and nonogenarians. The peak occurs in the fourth decade of life. It is more common in females than in males; the ratio is 3:2 [1].
Congenital thrombotic thrombocytopenic purpura (cTTP)
Intravenous infusion