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Tobramycin

Published
Topics: Eyes and visionInfection and infectious diseasesPatent expiries · Safety in BreastfeedingStability outside the fridgeTobramycin ·
Contents
  1. dm+d
  2. Articles
  3. Refrigerated Storage
    1. Tobi · Mylan
    2. Bramitob · Chiesi
    3. Vantobra · PARI Pharma GmbH 
  4. Lactation Safety Information
    1. Parenteral / Inhalation
    2. For ophthalmic use

dm+d

89695009

Articles

Safety in Lactation: Anti-infective eye preparations

30 October 2020Anti-infective preparations for ophthalmic use have limited systemic absorption in the mother, and pose negligible risk to a breastfed infant. Systemic absorption from eye drops…

Administration of tobramycin via a nebuliser

12 March 2020If there are robust clinical reasons to administer tobramycin injection via a nebuliser instead of using the licensed nebuliser solution then it is critical that…

Which commonly used nebuliser solutions are compatible?

27 February 2020Mixing of nebuliser solutions should only be undertaken in the best interests of the patient and only by a person competent and willing to do…

How should medicines be dosed in children who are obese?

18 October 2018Review on how to calculate medicine doses in children who are obese which includes a table on commonly prescribed medicines.

Safety in Lactation: Non-beta lactam antibiotics and antibacterials

20 August 2018paedAdditional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Aminoglycosides Only small or negligible amounts…
Search Articles

Refrigerated Storage

TobiMylan

Mylan
Tobi
Nebuliser solution 300mg/5ml

In the event of an inadvertent temperature excursion the following data may be used:
After removal from the refrigerator, or if refrigeration is unavailable, TOBI pouches (intact or opened) may be stored at up to 25°C for up to 28 days.

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk.

Contact Mylan in all cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.

Yes. If exposed to temperatures of up to 25°C, reduce the expiry date to 28 days from date of excursion.
No.
14 May 2020
London MI Service

BramitobChiesi

Chiesi
Bramitob
300 mg/4ml Nebuliser Solution

In the event of an inadvertent temperature excursion the following data may be used:
After first opening the single-dose container: use immediately.
In use shelf life: Bramitob bags (intact or opened) may be stored for up to 3 months at not more than 25°C by the end user
Prior to dispensing: Contact Chiesi in all cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.
Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

Yes
22 May 2019
London MI services

VantobraPARI Pharma GmbH 

PARI Pharma GmbH 
Vantobra
Nebuliser solution

The manufacturer does not hold stability data in addition to that provided in the Summary of Product Characteristics (SPC).

Please refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

5 August 2020
London MI Service

Lactation Safety Information

Parenteral / Inhalation

Parenteral / Inhalation
Caution
Gentamicin for parenteral use.
No aminoglycoside alternative for inhalation use
Limited published evidence of safety for parenteral use and no published evidence regarding administration via inhalation, although not considered to pose an increased risk
Small amounts in breast milk
Minimal absorption from the infant's GI tract
Safety in Lactation: Non-beta lactam antibiotics and antibacterials
11 September 2020
Bibliography

For ophthalmic use

For ophthalmic use
Yes
Safety in Lactation: Anti-infective eye preparations
11 September 2020
LactMed