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Safety in Lactation: Antidepressants

21 October 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Monamine-oxidase inhibitors (MAOIs) Due to the…

What is serotonin syndrome and which medicines cause it?

22 May 2020This Medicines Q&A outlines the causes and symptoms of serotonin syndrome and provides examples of medicines with the potential to cause serotonin syndrome.  
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Lactation Safety Information

TCA: imipramine/nortriptyline SSRI: paroxetine/sertraline
Tryptophan is an essential amino acid present in normal diet, and therefore found naturally in breast milk. It is converted to serotonin in the body. Widely available as a dietary supplement
Very limited published evidence of safety
There is theoretical but clinically unproven risk that therapeutic doses of tryptophan could increase serotonin levels in a breastfed infant, to which neonatal neurological development is especially sensitive
3 August 2020