Uteroglobin

Unassigned

New Medicines

Bronchopulmonary dysplasia - prevention in premature neonates with respiratory distress syndrome (RDS)

Information

New molecular entity
Therabron
Therabron

Development and Regulatory status

None
None
Phase II Clinical Trials
Yes
Yes

Category

Recombinant human uterglobin. A multifunctional, dimeric protein secreted predominately by cells lining the epithelial surface of the respiratory tract. Uteroglobin has anti-inflammatory properties in vivo &inhibits migration of neutrophils & macrophages.
BPD is a common complication of premature birth. Risk of developing BPD is inversely related to gestational age and birth weight. Figures for incidence vary depending on criteria used. Using oxygen dependency at 28 days as the defining criteria, a UK study found that approx. 50% of all admissions, weighing <1250 g, to a UK neonatal intensive care unit, developed BPD. Population-based studies show rates of BPD among surviving infants still hospitalised at 36 weeks after birth are 13-35% [1].
Bronchopulmonary dysplasia - prevention in premature neonates with respiratory distress syndrome (RDS)
Intratracheal
Parenteral