Valproic acid
Articles · Medicine Compliance Aid Stability · Lactation Safety Information · Published , updated
13965000
Articles
20th December 2018
Which medicines require extra care when switching between liquid and tablet/capsule formulations?
For a small number of medicines, there are differences in equivalent doses of oral formulations of the same medicine. This Q&A considers which medicines may… Alfacalcidol Carbamazepine Chloral hydrate Citalopram Clomethiazole Clozapine Co-amoxiclav Digoxin Emtricitabine Fusidic acid Itraconazole Lithium Mebeverine Medicine Medicines Safety Mercaptopurine Metronidazole Mycophenolate mofetil Mycophenolic acid Phenytoin Phenytoin sodium Posaconazole Q&A Raltegravir Selegiline Sirolimus Tenofovir Tipranavir Valproic acid Vardenafil
3rd January 2018
Safety in Lactation: Drugs for bipolar disorder and hypomania
Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Whilst valproate (valproic acid/sodium valproate) is… Asenapine Carbamazepine Lithium carbonate Lithium citrate Mental health and illness Obstetrics and gynaecology Paediatric and neonatal medicine Safety in Lactation Sodium valproate Valproic acid
8th December 2017
Suggestions for Therapeutic Drug Monitoring in Adults in Primary Care
This document is intended to support local discussions on how to monitor commonly prescribed high risk medicines in primary care. Comments have been included as… Acute Care Aminophylline Amiodarone Apixaban Aripiprazole Atorvastatin Azathioprine Candesartan Carbimazole Care homes Celecoxib Ciclosporin Community Health Services Dabigatran etexilate Diclofenac potassium Diclofenac sodium Digoxin Donepezil Dronedarone Edoxaban Enalapril Eplerenone Etoricoxib Galantamine Haloperidol Hydrocortisone Hydroxycarbamide Ibuprofen Leflunomide Levothyroxine Lisinopril Lithium Losartan Mental Health Mercaptopurine Mesalazine Methotrexate Mycophenolate mofetil Mycophenolic acid Naproxen News Nitrofurantoin Olanzapine Penicillamine Perindopril Phenytoin Phenytoin sodium Pioglitazone Pravastatin Prednisolone Primary Care Propylthiouracil Quetiapine Ramipril Risperidone Rivaroxaban Rivastigmine Rosuvastatin Simvastatin Sirolimus Sodium valproate Spironolactone Sulfasalazine Tacrolimus Telmisartan Theophylline Transfer of care Valproic acid Warfarin
17th December 2014
Can antiepileptics (anticonvulsants) increase the risk of osteoporosis?
This updated Medicines Q&A evaluates the evidence available on the risk of osteoporosis in patients with epilepsy taking antiepileptic drugs. Carbamazepine Clobazam Eslicarbazepine Ethosuximide Fosphenytoin Gabapentin Lacosamide Lamotrigine Levetiracetam Musculo-skeletal disorders Oxcarbazepine Perampanel Phenobarbital Phenobarbital sodium Phenytoin Phenytoin sodium Pregabalin Primidone Q&A Retigabine Rufinamide Sodium valproate Tiagabine Topiramate Valproic acid Vigabatrin ZonisamideMedicine Compliance Aid Stability
Depakote · Sanofi
Sanofi
Depakote
Tablets e/c 250mg, 500mg
A3 · Amber 3 · No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Protect from moisture
Protect from moisture. Max 7 days in MCA.
1st October 2015
Convulex · Pharmacia Ltd
Pharmacia Ltd
Convulex
Capsules e/c 150mg, 300mg, 500mg
R2 · Red 2 · Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Unsuitable for MCA as preparations are hygroscopic which can affect release profile.
2nd March 2015
Lactation Safety Information
For mania
For mania
Carbamazepine; Appropriate second generation antipsychotic
Significant published evidence of safety in breastfeeding indicates small amounts in breast milk
Monitor infant for jaundice, bruising, and bleeding
MHRA states that it should not used in women of child bearing age unless Pregnancy Prevention Programme is in place, and only if other treatments are ineffective or not tolerated. For this reason, carbamazepine is preferred first-line in breastfeeding (see summary)
22nd January 2020