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Dosing

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Oral benzodiazepines and choosing equivalent doses

2 July 2025Equivalent doses of oral benzodiazepines to diazepam are not exact. Consider these factors before switching.

Managing dosage adjustments for prescribed medicines

23 January 2025Advice on managing medicines that may require dosage adjustments after they have been prescribed.

Using St Mark’s electrolyte solution

31 January 2024St Mark’s solution is an oral rehydration solution, which maintains fluid balance in conditions like short bowel syndrome. We guide on preparation and use.

Using folic acid with methotrexate in rheumatoid arthritis

20 February 2023Folic acid is used to reduce methotrexate associated adverse effects in people with rheumatoid arthritis. This page guides appropriate dosing.

Reversing an adult opioid overdose with naloxone

18 October 2022A patient safety alert highlighted the risks of giving inappropriate doses of naloxone. We guide on using appropriate intravenous doses in the medical setting.

Understanding why PGDs cannot be used for dose adjustments

16 November 2021This article outlines why PGDs cannot be used to adjust the dosage of a medicine already in an individual's possession.

Dosing

All our advice relating to specific dosing recommendations.

Inclusion of dose ranges in a single Patient Group Direction

9 September 2020The below summarises the considerations required if a single PGD is to include a range of doses.

Supply of aseptically Prepared Doses of IMPs Across Legal Boundaries Version 2 October 2019

11 November 2019This document has been developed by the NHS Quality Assurance Committee and National Pharmacy Clinical Trials Advisory Group with input provided by the MHRA Clinical…

Guidance on Managing The Sourcing and Supply of Ready-to-Administer Chemotheraphy Doses for the NHS (Yellow Cover)

5 December 2016This document is aimed at staff in UK NHS hospitals considering or already sourcing their supply of chemotherapy as ready-to-administer doses.