What naloxone doses should be used in adults to urgently reverse the effects of opioids?

The opioid antagonist, naloxone, is a highly effective antidote the use of which is potentially life-saving. The drug has a role in a wide range…

Which opioids can be used in renal impairment?

Opioids are used in a wide variety of clinical settings and are well established for the treatment of both acute and chronic pain. Renal impairment…

In use product safety assessment report: Onexila® XL (oxycodone once daily prolonged release tablets)

A UKMi Product Safety assessment on Onexila® XL (oxycodone once daily prolonged release tablets); in-use medication safety considerations resultant from the product presentation or other…

What is serotonin syndrome and which medicines cause it?

This Medicines Q&A outlines the causes and symptoms of serotonin syndrome and lists examples of medicines with the potential to cause serotonin syndrome

What are the equivalent doses of oral morphine to other oral opioids when used as analgesics in adult palliative care?

Morphine is generally the strong opioid of choice for treating moderate to severe cancer pain and a common question is how to convert a dose…

Can opioids be used for pain relief during pregnancy?

There are no specific guidelines for the treatment of pain in pregnancy. Not all analgesics are suitable for use during or at certain stages of…

Safety in Lactation: Opioid analgesics

The evidence relating to the safe use of opioid analgesics in breastfeeding mothers is very variable between individual drugs. This group of drugs presents a…