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Safety in Lactation: Opioid analgesics

21 October 2020The evidence relating to the safe use of opioid analgesics in breastfeeding mothers is very variable between individual drugs. This group of drugs presents a…

What is serotonin syndrome and which medicines cause it?

22 May 2020This Medicines Q&A outlines the causes and symptoms of serotonin syndrome and provides examples of medicines with the potential to cause serotonin syndrome.  

Can opioids be used for pain relief during pregnancy?

7 May 2020There are no specific guidelines for the treatment of pain in pregnancy. Not all analgesics are suitable for use during or at certain stages of…

What naloxone doses should be used in adults to urgently reverse the effects of opioids?

19 December 2019The opioid antagonist, naloxone, is a highly effective antidote the use of which is potentially life-saving. The drug has a role in a wide range…

Review of high dose opioids in chronic non-malignant pain

12 April 2019The Faculty of Pain Medicine (Royal College of Anaesthetists) states that the morphine dose for which harms outweigh benefits is 120mg oral morphine or equivalent/24…

What are the equivalent doses of oral morphine to other oral opioids when used as analgesics in adult palliative care?

1 August 2018Morphine is generally the strong opioid of choice for treating moderate to severe cancer pain and a common question is how to convert a dose…

In use product safety assessment report: Onexila® XL (oxycodone once daily prolonged release tablets)

29 January 2018A UKMi Product Safety assessment on Onexila® XL (oxycodone once daily prolonged release tablets); in-use medication safety considerations resultant from the product presentation or other…