Depression and anxiety
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Using suitable formulations when deprescribing antidepressants
13 May 2026Tapering antidepressants to very low doses poses practical challenges. This page outlines licensed, off-label and unlicensed options.
SSRI suggestions for adults with swallowing difficulties
27 April 2026A range of selective serotonin reuptake inhibitor (SSRI) formulations are suitable for adults with swallowing difficulties.
Addressing inappropriate use of antidepressants for depression and anxiety
20 January 2026Deprescribing antidepressants involves safely reducing and withdrawing them. An introduction; signposting to current resources; and SPS resources coming soon.
Choosing an antidepressant for people with coronary heart disease
29 April 2025Sertraline is the first-line option in people with coronary heart disease. Alternatives include fluoxetine, paroxetine and mirtazapine.
Considerations when choosing an alternative antidepressant
17 September 2024Consider the risks associated with switching an antidepressant for depression, the patient's individual circumstances and when to seek specialist advice.
Monitoring a person during and after antidepressant switching
17 September 2024Review people at appropriate time points; advise on what to expect and report; and beware of the possibility of withdrawal symptoms and serotonin syndrome.
Planning and agreeing an antidepressant switching strategy
17 September 2024Guidance on planning and implementing the antidepressant switch after the need and choice of antidepressant have been decided.
Agomelatine to other antidepressants: switching in adults
17 September 2024Suggested methods for switching safely from agomelatine to other antidepressants. Switches requiring additional specialist support are highlighted.
Mirtazapine to other antidepressants: switching in adults
31 May 2024Suggested methods for switching safely from mirtazapine to other antidepressants. Switches requiring additional specialist support are highlighted.
SNRIs to other antidepressants: switching in adults
31 May 2024Suggested methods for switching safely between SNRIs or to other antidepressants. Switches requiring additional specialist support are highlighted.