Switching

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Equivalent doses of oral benzodiazepines

8 December 2020Benzodiazepines are the most commonly used anxiolytics and hypnotics. There are major differences in potency between different benzodiazepines and this difference in potency is important…

Switching between liquid and tablet/capsule formulations – Which medicines require extra care?

17 July 2020For a small number of medicines, there are differences in equivalent doses of oral formulations of the same medicine. This Q&A considers which medicines may…

Switching from doxazosin XL tablets to doxazosin standard release tablets

4 June 2020Both doxazosin standard release tablets and doxazosin XL tablets provide effective blood pressure control and both are effective in reducing the clinical symptoms of benign…

What is the equivalent dose of oral prednisolone to intravenous (IV) hydrocortisone?

29 May 2020Prednisolone 5mg orally is equivalent to hydrocortisone 20mg intravenously (equivalent anti-inflammatory dose). The peri-operative dose of hydrocortisone required may be higher than the equivalent prednisolone…

How do you switch between tricyclic, SSRI and related antidepressants?

21 October 2019This updated Medicines Q&A provides advice on the risks and suggested strategies for switching between tricyclic (TCA), selective serotonin reuptake inhibitors (SSRI) and related antidepressants.…

How do you switch between monoamine oxidase inhibitors and SSRI, tricyclic or related antidepressants?

9 September 2019This updated Medicines Q&A provides advice on the risks and suggested strategies for switching between monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRI),…

What are the equivalent doses of oral morphine to other oral opioids when used as analgesics in adult palliative care?

1 August 2018Morphine is generally the strong opioid of choice for treating moderate to severe cancer pain and a common question is how to convert a dose…

How do you switch between pregabalin and gabapentin for neuropathic pain, and vice versa?

30 August 2017This recently updated Medicines Q&A evaluates the limited published evidence available on managing a switch between pregabalin and gabapentin for neuropathic pain, and vice versa.