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Cautions and contraindications

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Choosing between oral vancomycin options

18 June 2025Organisations should choose suitable formulary options for oral vancomycin and mitigate risks. Several factors affect decision making.

Choosing between fidaxomicin options

18 June 2025Organisations should choose suitable fidaxomicin formulary options and mitigate risks. Several factors affect decision making.

Choosing an antidepressant for people with coronary heart disease

29 April 2025Sertraline is the first-line option in people with coronary heart disease. Alternatives include fluoxetine, paroxetine and mirtazapine.

Using NSAIDs in asthma

17 July 2024Safety and prescribing scenarios for using nonsteroidal anti-inflammatory drugs (NSAIDs) in adults with asthma are outlined.

Using intramuscular injections in people on oral anticoagulants

20 September 2023Advice on risks related to use of small volume (less than 3mL) intramuscular (IM) injections in people on oral anticoagulants (for example, DOACs, warfarin)

Managing constipation in people taking clozapine

14 October 2022Constipation in people taking clozapine can be fatal. Guidance on preventing and managing constipation in these individuals is described.

Considering sodium content of medicines

26 October 2021High sodium content can make some medicines unsuitable for patients on a salt-restricted diet. Alternative products exist for a range of conditions.

Cautions and contraindications

All our advice relating to specific cautions and contraindications, with recommendations on management options.

Using antidepressants for depression in people with epilepsy

14 May 2021Antidepressant use requires special consideration in people with epilepsy. Treating depression in stable epilepsy is covered.