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Understanding risks with intrathecal administration

13 June 2025The intrathecal route is a high-risk route of administration. Incorrect administration of medicines unsafe for this route can result in patient death.

Trastuzumab: informing intrathecal risk assessment

11 August 2022Trastuzumab products vary in their licensed status and other characteristics which affects their suitability for intrathecal administration

Topotecan: informing intrathecal risk assessment

11 August 2022Topotecan products vary in their licensed status and other characteristics which affects their suitability for intrathecal administration

Thiotepa: informing intrathecal risk assessment

11 August 2022Thiotepa products vary in their licensed status and other characteristics which affects their suitability for intrathecal administration

Switching between morphine and other opioids in palliative care

1 April 2025Switching between oral morphine and other oral opioids requires care and thoughtful application of a stepped process.

Rituximab: informing intrathecal risk assessment

11 August 2022Rituximab products vary in their licensed status and other characteristics which affects their suitability for intrathecal administration

Preventing harm from incorrect vinca alkaloid administration

13 June 2025Vinca alkaloids can cause paralysis and death if given by the wrong route. Understand how to reduce the risk to patients.

Methotrexate: informing intrathecal risk assessment

11 August 2022Methotrexate products vary in their licensed status and other characteristics which affects their suitability for intrathecal administration

Managing an intrathecal chemotherapy service

13 June 2025The intrathecal route is a high-risk route of administration. There are minimum requirements for providing intrathecal chemotherapy.

Hydrocortisone: informing intrathecal risk assessment

11 August 2022Hydrocortisone products vary in their licensed status and other characteristics which affects their suitability for intrathecal administration