How should medicines be dosed in children who are obese?

Obesity results in physiological changes that can affect the volume of distribution and the clearance of drugs. The extent of these changes is variable and…

In use product safety assessment report for intravenous paracetamol in paediatrics

In May 2010, the Medicines and Healthcare products Regulatory Agency (MHRA) issued a safety update to healthcare professionals in the UK highlighting the risk of…

What is the evidence to support the use of IV paracetamol for the short-term treatment of moderate to severe pain in adults?

There are vast numbers of studies assessing the efficacy of IV paracetamol in various clinical situations. Systematic reviews and meta-analyses are listed in this Q&A, grouped…

What advice should be given to people with porphyria who are undergoing dental procedures?

An indication of the safety of various medicines commonly used by dentists in patients with acute porphyria is given. When considering the safety of medicines…

Can breastfeeding mothers take paracetamol or paracetamol combination products?

This updated Medicines Q&A evaluates the available evidence for the safety of paracetamol in breastfeeding mothers. The updated version also contains information on paracetamol combination…

Safety in Lactation: Simple analgesics and combination analgesic preparations

Paracetamol is the simple analgesic of choice in breastfeeding mothers. Choice of an alternative will depend on level of analgesia required. Paracetamol should be adequate…

ARCHIVED NPSA Signal - Overdose of intravenous paracetamol in infants and children - October 2010

  Key risks emerging from the review of serious incidents reported by the NHS to its National Reporting and Learning System (NRLS) were shared in…

ARCHIVED NPSA Signal - Detecting harm following paracetamol overdose - October 2010

Key risks emerging from the review of serious incidents reported by the NHS to its National Reporting and Learning System (NRLS) were shared in in…