What naloxone doses should be used in adults to urgently reverse the effects of opioids?

The opioid antagonist, naloxone, is a highly effective antidote the use of which is potentially life-saving. The drug has a role in a wide range…

Shortage of procyclidine (Kemadrin) 5mg/ml injection

Accord is the only supplier of procyclidine injection in the UK and will be out of stock from November until March 2020. There is no…

National Ambulance Patient Group Directions

National PGDs have been developed for ambulance services commissioned by NHS England.  They are supported by NASMeD and JRCALC. Organisations need to adopt them locally in…

Patient Group Directions for Chemical, Biological, Radiological and Nuclear (CBRN) incidents

A specific set of PGDs have been developed by Public Health England (PHE) in partnership with NHS England, the Department of Health and Social Care…

Regional Medicines Optimisation Committee Antidotes and RUMs Position Statement

Attached is the final position statement produced by the London RMOC on access to and availability of antidotes and rarely used medicines (RUMs) published in…

Shortage of Diazemuls (diazepam 5mg/ml emulsion for injection)

Accord (sole supplier) is expected to be out of stock from 17th March until September/October 2020 but dates are not yet confirmed. Importers are unable…

In use product safety assessment report: naloxone products for emergency opiate reversal in non-medical settings

A UKMi Product Safety assessment on naloxone products for emergency opiate reversal in non-medical settings; in-use medication safety considerations resultant from the product presentation or…

LMEN: Summary of antidotes to NOACs (including those currently in development) which could impact NOAC use in the future

NOACs offer convenient fixed dosing without need for routine coagulation monitoring and they have predictable pharmacokinetics, fewer interactions and quicker onset (and offset) of action…