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How do you convert an oral pyridostigmine or neostigmine dose to a parenteral neostigmine dose?

23 April 2020This updated Medicines Q&A gives suggested dose conversions from oral pyridostigmine or neostigmine to parenteral neostigmine and includes example dose conversion calculations

What advice should be given to patients with porphyria who intend to travel?

20 December 2019Most travel vaccines are safe in the acute porphyrias, but there has been an unpublished report of an acute porphyria attack following yellow fever vaccination.…

Product Risk Assessment Tools

15 March 2016Product risk assessment tools to support NHS organisations to identify risk resultant from medicinal product presentation.

Non-vitamin K antagonist oral anticoagulants (NOACs): Is it safe to take them with herbal medicines?

26 March 2020There is a lack of scientific evidence of the safety and efficacy of herbal medicines together with an under-reporting and underestimation of adverse effects. Interactions…

How do amlodipine and felodipine compare for the treatment of hypertension or prophylaxis of stable angina?

25 September 2020This updated Medicines Q&A reviews the data available to assist decision-making when choosing and switching between amlodipine and felodipine for the treatment of hypertension or…

Does St John’s Wort interact with combined and progestogen only hormonal contraception?

1 June 2020This updated Medicines Q&A evaluates the available evidence regarding an interaction between St John’s Wort and combined and progestogen only hormonal contraceptives. Summary The interaction…

Can low dose aspirin be used in breastfeeding mothers as an antiplatelet agent?

29 October 2020Limited data and pharmacokinetics indicate that low dose aspirin (defined here as 75 – 150mg daily) passes into breast milk in small amounts. There…

What is the Dose of Folic Acid to use with Methotrexate therapy for Rheumatoid Arthritis?

5 October 2012This updated Q&A notes that there remains no definitive answer regarding the optimal dose of folic acid for patients with rheumatoid arthritis who are being…

Guidance for the Approval of Suppliers of Raw Materials Used in the Manufacture of Unlicensed Medicinal Products 3rd edition (Yellow Cover)

25 May 2010This document is intended to provide a guidance framework for NHS Specials’ manufacturing activity for a consistent and risk-based approach to evaluate and approve suppliers…

Monitoring of isolators and Enclosed Spaces Sterilised by Hydrogen Peroxide Vapour 1st edition (Yellow Cover)

25 May 2010The principal aim of this paper is to provide guidance on the requirement for microbial monitoring during aseptic preparation sessions although other aspects are included.…

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