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Antiplatelet formulations suggested for adults with swallowing difficulties

1 July 2021A range of antiplatelets are suitable for use in adults with swallowing difficulties.

Can low dose aspirin be used in breastfeeding mothers as an antiplatelet agent?

29 October 2020Limited data and pharmacokinetics indicate that low dose aspirin (defined here as 75 – 150mg daily) passes into breast milk in small amounts.   There…

Safety in Lactation: Simple analgesics and combination analgesic preparations

26 October 2020Paracetamol is the simple analgesic of choice in breastfeeding mothers. Choice of an alternative will depend on level of analgesia required. Paracetamol should be adequate…

Safety in Lactation: Drugs for thromboembolic disorders

18 September 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Oral anticoagulants The coumarin anticoagulants, warfarin…

Can nonsteroidal anti-inflammatory drugs be used in adult patients with asthma?

9 June 2020NSAIDs are contra-indicated in patients in whom attacks of asthma have been precipitated by aspirin or any other NSAID. Further studies are required to confirm…
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Medicine Compliance Aid Stability

MicropirinDexcel Pharma Ltd

Dexcel Pharma Ltd
Micropirin
Tablets e/c 75mg, 300mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from moisture
Aspirin gradually hydrolyses in moist air and emits a vinegar-like odour. Must be protected from moisture and heat.
9 November 2015

NuSeals AspirinAlliance Pharmaceuticals

Alliance Pharmaceuticals
NuSeals Aspirin
Tablets e/c 75mg, 300mg
G1 · Green 1Stability data indicates that the drug is suitable for CAs and there are no theoretical concerns with the product.
Airtight container
Protect from moisture
Short term stability in compliance aids (therefore store for a maximum of 8 days in MCA). Store in airtight containers. Protect from moisture.
27 April 2015

genericNon-proprietary

Non-proprietary
generic
Tablets 300mg
A1 · Amber 1Stability data is available in an alternative container (not CAs) that may be extrapolated to support storage in CAs.
Protect from moisture
Drug hydrolyses in moist air and the rate of hydrolysis is increased by heat. Maximum 8 days in compliance aid.
11 May 2015

genericNon-proprietary

Non-proprietary
generic
Tablets dispersible 75mg, 300mg
A1 · Amber 1Stability data is available in an alternative container (not CAs) that may be extrapolated to support storage in CAs.
Protect from moisture
Drug hydrolyses in moist air and the rate of hydrolysis is increased by heat. Maximum 8 days in MCA.
11 May 2015

CaprinPinewood Healthcare

Pinewood Healthcare
Caprin
Tablets e/c, f/c 75mg, 300mg
A1 · Amber 1Stability data is available in an alternative container (not CAs) that may be extrapolated to support storage in CAs.
Protect from moisture
Drug hydrolyses in moist air and the rate of hydrolysis is increased by heat. Maximum 8 days in compliance aid.
11 May 2015

NuSealsAlliance Pharmaceuticals

Alliance Pharmaceuticals
NuSeals
Tablets e/c 75mg, 300mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from moisture
Aspirin gradually hydrolyses in moist air and emits a vinegar-like odour. Must be protected from moisture and heat.
9 November 2015

Lactation Safety Information

Low dose as antiplatelet agent

Low dose as antiplatelet agent
Clopidogrel, Dipyridamole
Low doses (75-150mg daily) considered low risk.
Very limited published evidence for use of low-dose aspirin during breastfeeding with no adverse effects reported.
Do not use if the infant has a viral infection or fever. There is a theoretical risk of an association with Reye’s syndrome, even at low doses especially in children with a viral infection or fever.
Used in full-term neonates from birth.
Monitor infant for signs of bruising or bleeding, which may be prolonged.
8 October 2021

For pain

For pain
Paracetamol, Ibuprofen
Use only if other simple analgesics, such as paracetamol or ibuprofen, are not suitable.
Three separate case reports of adverse effects in breastfed infants; metabolic acidosis following high-dose, maternal use, thrombocytopenic purpura (dose and treatment length not specified) and hemolysis in infant with G6PD deficiency.
Monitor infant for signs of bruising or bleeding, which may be prolonged
Do not use if the infant has a viral infection or fever. There is a theoretical risk of an association with Reye’s syndrome, even at low doses especially in children with a viral infection or fever.
12 July 2021