Licensed for intrathecal use
Products licensed for intrathecal use are the first line option and should be used wherever suitable.
There are currently no known etoposide products licensed for intrathecal administration.
Not licensed for intrathecal use, limited information available
Products with partial information that are not licensed for intrathecal administration can still sometimes be used. Refer to the advice in our article and complete a risk assessment to enable you to interpret the details below and choose an appropriate product.
Accord
Strength
20mg/mL in 5mL vial
20mg/mL in 10mL vial
20mg/mL in 12.5mL vial
20mg/mL in 20mL vial
20mg/ml in 25mL vial
20mg/mL in 50mL vial
Excipients
Citric acid, anhydrous, benzyl alcohol (30 mg/ml), polysorbate 80, macrogol 300, ethanol, anhydrous (240.64 mg/ml)
Osmolarity
No information
pH
3.0 – 4.0
Endotoxin content
≤ 1.3 EU/mg
Actavis
Strength
Excipients
Macrogol 400, polysorbate 80, ethanol (anhydrous), citric acid, anhydrous (for pH adjustment)
Osmolarity
> 2000 mOsmol/L
pH
3.0 – 4.0
Endotoxin content
No information
Bristol-Myers Squibb (Etopophos®)
Strength
Excipients
Dextran 40, Sodium citrate
Osmolarity
No information
pH
No information
Endotoxin content
No information
Fresenius
Strength
20mg/mL in 5mL vial
20mg/mL in 10mL vial
20mg/mL in 25mL vial
20mg/mL in 50mL vial
Excipients
Macrogol 300, polysorbate 80, benzyl alcohol (30mg/mL), ethanol (241.4 mg/mL), citric acid (anhydrous)
Osmolarity
No information
pH
No information
Endotoxin content
≤ 2.0 EU/mg
Medac
Strength
20mg/mL in 5mL vial
20mg/mL in 25mL vial
20mg/mLin 50mL vial
Excipients
Macrogol 300, polysorbate 80, ethanol, citric acid (anhydrous)
Osmolarity
No information
pH
No information
Endotoxin content
No information
Neon (Etopophos®)
Strength
Excipients
Dextran 40, Sodium citrate
Osmolarity
No information
pH
No information
Endotoxin content
≤ 0.47 EU/mg
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