Interactions
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Managing interactions between macrolides and statins
12 July 2024The use of statins can be continued with azithromycin. However, the interaction risks need to be managed if clarithromycin or erythromycin are required.
Understanding enzyme or transporter-based drug interactions
5 July 2024Many interactions are due to inhibition or induction of metabolising enzymes or drug transporters. Enzyme, transporter, and drug half-lives dictate duration.
Understanding drug interactions
22 May 2024This article discusses different mechanisms of drug interactions. We link to other SPS articles to help support decision making.
Using folic acid and phenytoin safely
12 April 2024Folic acid interacts with phenytoin and can reduce phenytoin blood levels. Concomitant use is possible with careful management of the interaction.
Understanding direct oral anticoagulant (DOAC) interactions
5 January 2024It is important to understand the risks, mechanisms of interactions and actions to take when prescribing medicines with DOACs.
Considering drug interactions with smoking
8 November 2023Tobacco smoke can induce liver enzymes, affecting drug metabolism. Some medicines may need dose adjustment or monitoring if a person stops or starts smoking.
Managing specific interactions with smoking
31 October 2023When individuals taking certain medicines stop, start or re-start smoking, monitoring and dose changes may be needed.
Using clopidogrel with proton pump inhibitors (PPIs)
14 September 2023Avoid the combined use of clopidogrel with omeprazole or esomeprazole due to a significant interaction. Other PPIs are considered safe with clopidogrel.
Using warfarin with proton pump inhibitors (PPIs)
19 April 2023PPIs may enhance warfarin anticoagulation. Patients on warfarin require counselling when starting on a PPI and INR monitored appropriately.
Using bisphosphonates with proton pump inhibitors (PPIs)
4 April 2023Although no interaction between bisphosphonates and PPIs is documented, the increased risk of fractures when given together should be reviewed and managed