Amitriptyline

Choosing an antidepressant for people with coronary heart disease

29 April 2025Sertraline is the first-line option in people with coronary heart disease. Alternatives include fluoxetine, paroxetine and mirtazapine.

Managing interactions with local anaesthetics in dentistry

3 January 2025Most drug interactions with local anaesthetics (LA) cartridges are not clinically relevant in general dentistry. We advise on management options where needed.

Managing specific interactions with smoking

31 October 2023When individuals taking certain medicines stop, start or re-start smoking, monitoring and dose changes may be needed.

Tricyclics to other antidepressants: switching in adults

17 February 2023Suggested methods for switching safely between tricyclics or to other antidepressants. Switches requiring additional specialist support are highlighted.

Using tricyclic antidepressants during breastfeeding

31 January 2023Imipramine and nortriptyline are the tricyclic antidepressants of choice. Recommendations apply to full term and healthy infants only.