How do you switch between tricyclic, SSRI and related antidepressants?

This updated Medicines Q&A provides advice on the risks and suggested strategies for switching between tricyclic (TCA), selective serotonin reuptake inhibitors (SSRI) and related antidepressants.…

What is the most appropriate antidepressant to use in people with epilepsy?

NICE recommend that non-pharmacological interventions such as CBT should be considered in people presenting with depression, in addition to the use of antidepressants. With respect…

What is the antidepressant of choice in coronary heart disease (CHD)?

This updated Q&A describes the limited data on antidepressant use in patients with coronary heart disease.

Safety in Lactation: Antidepressants

Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Monamine-oxidase inhibitors (MAOIs) Due to the…

Can tricyclic antidepressants cause tinnitus?

This Medicines Q&A evaluates the limited published evidence available on whether tricyclic antidepressants can cause tinnitus.

If antidepressant-induced hyponatraemia has been diagnosed, how should the depression be treated?

This Medicines Q&A evaluates the evidence available on the management of depression in patients with antidepressant-induced hyponatraemia.  

What is serotonin syndrome and which medicines cause it?

This Medicines Q&A outlines the causes and symptoms of serotonin syndrome and lists examples of medicines with the potential to cause serotonin syndrome

Management of depression in breastfeeding mothers - are tricyclic antidepressants safe?

Estimates of the amount of TCA ingested by an infant via breast milk are of the order of 0.2 – 4% of the weight adjusted…