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What is serotonin syndrome and which medicines cause it?

22 May 2020This Medicines Q&A outlines the causes and symptoms of serotonin syndrome and provides examples of medicines with the potential to cause serotonin syndrome.  

How do you switch between tricyclic, SSRI and related antidepressants?

21 October 2019This updated Medicines Q&A provides advice on the risks and suggested strategies for switching between tricyclic (TCA), selective serotonin reuptake inhibitors (SSRI) and related antidepressants.…

What is the risk of gastrointestinal bleeding associated with selective serotonin reuptake inhibitors (SSRIs)?

17 October 2019Observational study results have indicated that there is an association between the use of SSRIs and upper GI bleeds, with a number needed to harm…

Is there a lactose-free antidepressant?

24 September 2019This Medicine Q&A lists currently available lactose-free antidepressant preparations. There is a lactose-free preparation available for all antidepressants except for clomipramine, doxepin, isocarboxazid, moclobemide, nortriptyline…

If antidepressant-induced hyponatraemia has been diagnosed, how should the depression be treated?

10 June 2019This Medicines Q&A evaluates the evidence available on the management of depression in patients with antidepressant-induced hyponatraemia. Summary Most antidepressants are associated with hyponatraemia, with…

Triptans and SSRI or SNRI antidepressants – is there an interaction?

27 March 2019The likelihood of an interaction between triptans and SSRIs/SNRIs resulting in serotonin syndrome is considered in this updated Medicines Q&A.

Tamoxifen and SSRI or SNRI antidepressants – is there an interaction?

15 February 2019This updated Medicines Q&A reviews the evidence for an interaction between tamoxifen and selective serotonin reuptake inhibitors (SSRIs)/serotonin noradrenaline reuptake inhibitors (SNRIs) resulting in reduced…

What is the most appropriate antidepressant to use in people with epilepsy?

29 January 2019NICE recommend that non-pharmacological interventions such as CBT should be considered in people presenting with depression, in addition to the use of antidepressants. With respect…

What is the antidepressant of choice in coronary heart disease (CHD)?

2 October 2018This updated Q&A describes the limited data on antidepressant use in patients with coronary heart disease.