Tamoxifen and SSRI or SNRI antidepressants – is there an interaction?

This updated Medicines Q&A reviews the evidence for an interaction between tamoxifen and selective serotonin reuptake inhibitors (SSRIs)/serotonin noradrenaline reuptake inhibitors (SNRIs) resulting in reduced…

What is the most appropriate antidepressant to use in people with epilepsy?

NICE recommend that non-pharmacological interventions such as CBT should be considered in people presenting with depression, in addition to the use of antidepressants. With respect…

What is the antidepressant of choice in coronary heart disease (CHD)?

This updated Q&A describes the limited data on antidepressant use in patients with coronary heart disease.

If antidepressant-induced hyponatraemia has been diagnosed, how should the depression be treated?

This updated Medicines Q&A evaluates the evidence available on the management of depression in patients with antidepressant-induced hyponatraemia.  

What is serotonin syndrome and which medicines cause it?

This Medicines Q&A outlines the causes and symptoms of serotonin syndrome and lists examples of medicines with the potential to cause serotonin syndrome

What is the risk of gastrointestinal bleeding associated with selective serotonin reuptake inhibitors (SSRIs)?

The results from most, but not all observational studies suggest that there is an association between the use of SSRIs and upper GI bleeds. Several…

What is the risk of developing Serotonin Syndrome following concomitant use of tramadol with selective serotonin reuptake inhibitors (SSRIs)?

This updated Medicines Q&A evaluates the published evidence available on the risk of developing serotonin syndrome following concomitant use of tramadol with selective serotonin reuptake…

Management of depression in breastfeeding mothers - are selective serotonin reuptake inhibitors (SSRIs) safe?

SSRIs and their metabolites pass into breast milk in small amounts, generally below 7% of the weight adjusted maternal dose. Infant ingestion via milk is…