Omeprazole

PPI suggestions for adults with swallowing difficulties

18 December 2025A range of proton pump inhibitor (PPI) formulations are suitable for adults with swallowing difficulties.

Managing interactions with methotrexate

30 June 2025Guidance on frequently asked questions on medicine interactions with low dose methotrexate.

Treating heartburn and dyspepsia during breastfeeding

5 March 2024Antacids, alginates, H2-receptor antagonists or proton pump inhibitors can be used during breastfeeding. Recommendations are for full term and healthy infants.

Using clopidogrel with proton pump inhibitors (PPIs)

14 September 2023Avoid the combined use of clopidogrel with omeprazole or esomeprazole due to a significant interaction. Other PPIs are considered safe with clopidogrel.

Using warfarin with proton pump inhibitors (PPIs)

19 April 2023PPIs may enhance warfarin anticoagulation. Patients on warfarin require counselling when starting on a PPI and INR monitored appropriately.

Using bisphosphonates with proton pump inhibitors (PPIs)

4 April 2023Although no interaction between bisphosphonates and PPIs is documented, the increased risk of fractures when given together should be reviewed and managed