Cardiovascular system disorders
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Using calcium-channel blockers during breastfeeding
2 June 2023Nifedipine and verapamil are the calcium-channel blockers of choice during breastfeeding. Recommendations apply to full term and healthy infants only.
Using clopidogrel with proton pump inhibitors (PPIs)
22 May 2023Avoid the combined use of clopidogrel with omeprazole or esomeprazole due to a significant interaction. Other PPIs are considered safe with clopidogrel.
Using angiotensin-II receptor antagonists during breastfeeding
11 May 2023Very limited data suggest breastmilk levels are likely to be low, but other medicine classes are preferred. Recommendations apply to full term, healthy infants.
Using lipid-lowering medicines during breastfeeding
21 April 2023Rosuvastatin, pravastatin and atorvastatin are preferred; simvastatin and ezetimibe can also be used. Recommendations apply to full term and healthy infants.
Identifying risk factors for developing a long QT interval
29 March 2023Some medicines (erythromycin, citalopram, ondansetron) can cause a long QT interval. Consider risk factors and follow MHRA recommendations for safe use.
Using ACE inhibitors during breastfeeding
28 March 2023Enalapril is the angiotensin converting enzyme (ACE) inhibitor of choice during breastfeeding. Recommendations apply to full term and healthy infants only.
Managing peripheral oedema caused by calcium channel blockers
26 September 2022All calcium channel blockers may cause peripheral oedema. There are different treatment options and the incidence can be affected by different factors.