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Haematological disorders

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Vitamin B12 deficiency: treatment during pregnancy

25 April 2022Intramuscular hydroxocobalamin is the preferred treatment choice for management of clinically relevant vitamin B12 deficiency, including during pregnancy.

Dosing and monitoring for treatment of Vitamin D deficiency in pregnancy

24 March 2021Effective treatment of vitamin D deficiency in pregnancy requires consideration of treatment regimens, monitoring, and preferred forms of vitamin D.

Using COVID-19 vaccines in patients with anticoagulation and bleeding disorders

7 January 2021Information on use of the vaccine in patients who are receiving anticoagulants or have a bleeding disorder is given below.

Safety in Lactation: Drugs used in hypoplastic, haemolytic, and renal anaemias

23 September 2020Biosynthetic erythropoietins are almost clinically indistinguishable from the natural form of erythropoietin, which is a normal component of breast-milk. They will not be absorbed from…

Safety in Lactation: Parenteral iron

23 September 2020Maternal iron supplementation for iron deficiency anaemia presents no risk to the breastfed infant as maternal iron is transported very poorly into breast milk. Although…

Oral vitamin B12 – what are the prescribing considerations and what formulations are available?

29 June 2020This Medicines Q&A outlines what oral vitamin B12 (cyanocobalamin) preparations are available and associated prescribing considerations. Hydroxocobalamin 1mg administered intramuscularly (IM) is the preferred method…

Low molecular weight heparins - should treatment doses be used in patients with renal impairment?

25 March 2020Randomised controlled trials evaluating LMWH efficacy and safety have generally excluded patients with severe renal impairment (RI). In contrast to UFH, LMWHs are primarily cleared…

Low molecular weight heparins - should prophylactic doses be used in patients with renal impairment?

23 October 2019This updated Medicines Q & A reviews the evidence available and considers when prophylactic doses of low molecular weight heparins can be used in patients…

Ravulizumab

Crizanlizumab