Mental health and illness
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Prescribing available medicines to treat ADHD
11 December 2025The availability of medicines used to treat Attention Deficit Hyperactivity Disorder (ADHD) varies currently. Supply content is maintained regularly by DHSC.
Using antipsychotics during breastfeeding
14 July 2025Quetiapine is the preferred second-generation, and haloperidol the preferred first-generation antipsychotic when breastfeeding full term, healthy infants.
Trazodone to other antidepressants: switching in adults
31 May 2024Suggested methods for switching safely from trazodone to other antidepressants. Switches requiring additional specialist support are highlighted.
Using SSRI antidepressants during breastfeeding
17 November 2023Paroxetine and sertraline are the Selective Serotonin Reuptake Inhibitors (SSRIs) of choice. Recommendations apply to full term and healthy infants only.
Establishing if a person needs to switch their antidepressant
28 March 2023Prior response, side-effects, new contraindications, and current depression symptoms may require switching antidepressants. When it is, establish shared goals.
Monitoring a person during and after antidepressant switching
17 September 2024Review people at appropriate time points; advise on what to expect and report; and beware of the possibility of withdrawal symptoms and serotonin syndrome.
Continuing management of the ADHD medicines shortage
15 July 2024Support for the system in continuing to manage supply disruption of medicines used to treat Attention Deficit Hyperactivity Disorder (ADHD).
Deprescribing of antidepressants for depression and anxiety
4 December 2023Deprescribing antidepressants involves safely reducing and withdrawing them. An introduction; signposting to current resources; and SPS resources coming soon.
Choosing an antidepressant for people with coronary heart disease
29 April 2025Sertraline is the first-line option in people with coronary heart disease. Alternatives include fluoxetine, paroxetine and mirtazapine.
Treating bipolar disorder during breastfeeding
3 April 2024Lithium and valproate can be used during breastfeeding, after consideration of some specific issues. Recommendations apply to full term and healthy infants.