Interactions
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Interactions
All our advice relating to medicine interactions, with recommendations on management options.
Using folic acid and phenytoin safely
12 April 2024Folic acid interacts with phenytoin and can reduce phenytoin blood levels. Concomitant use is possible with careful management of the interaction.
Understanding drug interactions
22 May 2024This article discusses different mechanisms of drug interactions. We link to other SPS articles to help support decision making.
Managing interactions between medicines and enteral feeds
18 September 2025Learn about the types of feed, some of the most common medicine and feed interactions and how to manage them.
Managing specific interactions with smoking
31 October 2023When individuals taking certain medicines stop, start or re-start smoking, monitoring and dose changes may be needed.
Managing interactions with methotrexate
30 June 2025Guidance on frequently asked questions on medicine interactions with low dose methotrexate.
Managing interactions between macrolides and statins
12 July 2024The use of statins can be continued with azithromycin. However, the interaction risks need to be managed if clarithromycin or erythromycin are required.
Using clopidogrel with proton pump inhibitors (PPIs)
14 September 2023Avoid the combined use of clopidogrel with omeprazole or esomeprazole due to a significant interaction. Other PPIs are considered safe with clopidogrel.
Managing complementary products and conventional medicines
13 January 2026Considerations when managing interactions with supplements and complementary, herbal and alternative products, including homeopathy, Chinese and Ayurvedic.
Understanding direct oral anticoagulant (DOAC) interactions
5 January 2024It is important to understand the risks, mechanisms of interactions and actions to take when prescribing medicines with DOACs.