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Interactions

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Herbal interactions: resources to support answering questions

28 March 2024Suggested resources to help healthcare professionals find information to answer questions about herbal interactions.

Managing interactions between macrolides and statins

24 November 2023The use of statins can be continued with azithromycin. However, the interaction risks need to be managed if clarithromycin or erythromycin are required.

Managing interactions with methotrexate

28 December 2023Guidance on frequently asked questions on medicine interactions with low dose methotrexate.

Considering drug interactions with smoking

31 October 2023Tobacco smoke can induce liver enzymes, affecting drug metabolism. Some medicines may need dose adjustment or monitoring if a person stops or starts smoking.

Drug interactions: resources to support answering questions

19 January 2023Suggested resources to help primary care healthcare professionals find information to answer questions about drug interactions

Understanding complementary medicines

28 March 2024Points to consider when advising on the use of complementary medicines.

Managing interactions with direct oral anticoagulants (DOACs)

5 January 2024Interactions with apixaban, dabigatran, edoxaban or rivaroxaban can result in increased risks of a bleed or thrombosis. We advise on management options.

Understanding enzyme or transporter-based drug interactions

22 May 2024Many interactions are due to inhibition or induction of metabolising enzymes or drug transporters. Enzyme, transporter, and drug half-lives dictate duration.

Identifying risk factors for developing a long QT interval

29 March 2023Some medicines (erythromycin, citalopram, ondansetron) can cause a long QT interval. Consider risk factors and follow MHRA recommendations for safe use.

Managing interactions with local anaesthetics in dentistry

3 January 2025Most drug interactions with local anaesthetics (LA) cartridges are not clinically relevant in general dentistry. We advise on management options where needed.