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Depression and anxiety

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Tricyclics to other antidepressants: switching in adults

31 May 2024Suggested methods for switching safely between tricyclics or to other antidepressants. Switches requiring additional specialist support are highlighted.

Trazodone to other antidepressants: switching in adults

31 May 2024Suggested methods for switching safely from trazodone to other antidepressants. Switches requiring additional specialist support are highlighted.

MAOI to other antidepressants: switching in adults

31 May 2024Switching between or from a monoamine oxidase inhibitor (MAOI) is a complex switch and requires support from a specialist. General principles are described.

SSRIs to other antidepressants: switching in adults

31 May 2024Suggested methods for switching safely between SSRIs or to other antidepressants. Switches requiring additional specialist support are highlighted.

Vortioxetine to other antidepressants: switching in adults

31 May 2024Suggested methods for switching safely from vortioxetine to other antidepressants. Switches requiring additional specialist support are highlighted.

Switching strategies for antidepressants

22 May 2024The choice of antidepressant switching strategy depends on the person and antidepressant. We describe the current strategies and their application.

Using tricyclic antidepressants during breastfeeding

17 November 2023Imipramine and nortriptyline are the tricyclic antidepressants of choice. Recommendations apply to full term and healthy infants only.

Using SSRI antidepressants during breastfeeding

17 November 2023Paroxetine and sertraline are the Selective Serotonin Reuptake Inhibitors (SSRIs) of choice. Recommendations apply to full term and healthy infants only.

Using certain antidepressants during breastfeeding

17 November 2023Duloxetine, mirtazapine, trazodone or venlafaxine can be used with caution but other options are preferred. Recommendations apply to full term, healthy infants.

Establishing if a person needs to switch their antidepressant

28 March 2023Prior response, side-effects, new contraindications, and current depression symptoms may require switching antidepressants. When it is, establish shared goals.