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Cautions and contraindications

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Supportive medicines guidance for adults on CAR-T cell therapy

11 February 2026This document provides expert clinical pharmacy guidance on supportive medicines in order to facilitate the treatment of complex CAR-T Cell Therapy patients.

Diagnosing and managing acute CAR-T cell toxicities in adults

11 February 2026Consensus guidance (involving Wave 1 and 2 CAR-T centres) on the management of acute CAR-T cell toxicities.

Medication restrictions for CAR-T cell therapy

11 February 2026CAR-T Therapy requires some medicines to be restricted, this guidance provides details and recommended wash-out periods for restricted medicines.

Choosing between fidaxomicin options

18 June 2025Organisations should choose suitable fidaxomicin formulary options and mitigate risks. Several factors affect decision making.

Choosing between oral vancomycin options

18 June 2025Organisations should choose suitable formulary options for oral vancomycin and mitigate risks. Several factors affect decision making.

Choosing an antidepressant for people with coronary heart disease

29 April 2025Sertraline is the first-line option in people with coronary heart disease. Alternatives include fluoxetine, paroxetine and mirtazapine.

Using NSAIDs in asthma

17 July 2024Safety and prescribing scenarios for using nonsteroidal anti-inflammatory drugs (NSAIDs) in adults with asthma are outlined.

Using antidepressants for depression in people with epilepsy

21 February 2024Antidepressant use requires special consideration in people with epilepsy. Treating depression in stable epilepsy is covered.

Using intramuscular injections in people on oral anticoagulants

20 September 2023Advice on risks related to use of small volume (less than 3mL) intramuscular (IM) injections in people on oral anticoagulants (for example, DOACs, warfarin)

Managing constipation in people taking clozapine

14 October 2022Constipation in people taking clozapine can be fatal. Guidance on preventing and managing constipation in these individuals is described.