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Articles

What injections can be given orally or via enteral feeding tubes?

6 November 2020This updated Medicines Q&A is a quick reference summary to different types of enteral feeding tubes, in relation to medication issues. Not all enteral feeding…

Safety in Lactation: Antimigraine drugs

21 October 2020If simple analgesics, e.g. paracetamol and ibuprofen, are insufficient to treat symptoms, sumatriptan is the drug of choice for the treatment of acute migraine. Although…

Safety in Lactation: Drugs for hypertension

23 September 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Many of the drugs covered by…

Shortage of clonidine 25microgram tablets

14 July 2020Accord are out of stock and unable to advise on a resupply date. Sandoz are out of stock but expect to have further supplies week…

How can hot flushes in men being treated for prostate cancer be managed?

28 April 2020This updated Medicines Q&A evaluates the available evidence for the different treatment options for hot flushes in men treated for prostate cancer
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Medicine Compliance Aid Stability

CatapresBoehringer Ingelheim

Boehringer Ingelheim
Catapres
Tablets 100 micrograms
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Store in airtight, light-resistant containers.
9 November 2015

genericNon-proprietary

Non-proprietary
generic
Tablets 25 micrograms
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Store in airtight and light resistant containers.
11 May 2015

DixaritBoehringer Ingelheim

Boehringer Ingelheim
Dixarit
Tablets s/c 25 micrograms
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Store in airtight and light resistant containers.
11 May 2015

Lactation Safety Information

For hypertension

For hypertension
Alternative appropriate antihypertensive
Moderate published evidence of safety
Moderate to significant amounts in breast milk
May interfere with lactation
Possible adverse reaction (unconfirmed, single case report) in a breastfed infant
Monitor infant for hypotension
23 September 2020

For migraine

For migraine
Propranolol/ Metoprolol
May interfere with lactation
Moderate level of published evidence of use in breastfeeding
For prophylaxis of migraine
Moderate to significant amounts in breast milk
23 September 2020

New Medicines

ValidiveMucositis; radiotherapy-induced in head and neck cancer

Information

Validive
New formulation
BioAlliance Pharma
BioAlliance Pharma

Development and Regulatory status

Phase II Clinical Trials
Phase II Clinical Trials
Phase II Clinical Trials
Yes
Yes

Category

Agonist to imidazoline & alpha 2 adrenergic receptors, once-daily extended-release
Oral mucositis affects ~ 2 in 10,000 people in the EU (equivalent to around 101,000 people). Severe oral mucositis occurs in 60% of pts with head and neck cancer having radiotherapy & may induce intense oral pain and eating disability requiring artificial nutritional support. In 20 to 30% of cases, pts have to be hospitalised & the disease may result in modification or discontinuation of radiotherapy in more than 10% of them [3].
Mucositis; radiotherapy-induced in head and neck cancer
Buccal