Clonidine

Articles · Medicine Compliance Aid Stability · Lactation Safety Information · New Medicines ·

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Articles

Drug-induced hypersalivation – what treatment options are available?

This Medicines Q&A summarises published studies or case reports concerning the pharmacological treatment of drug-induced hypersalivation (drooling or sialorrhoea), particularly hypersalivation caused by clozapine.   Amisulpride Atropine Benzatropine Biperiden Botulinum A toxin Bupropion Clonidine Clozapine Glycopyrronium Guanfacine Hyoscine butylbromide Hyoscine hydrobromide Ipratropium Lofexidine Metoclopramide Moclobemide Oxybutynin Pirenzepine Propantheline Q&A Quetiapine Sulpiride Trihexyphenidyl

Medicine Compliance Aid Stability

Catapres · Boehringer Ingelheim

Boehringer Ingelheim
Catapres
Tablets 100 micrograms
A3 · Amber 3 · No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Store in airtight, light-resistant containers.
9th November 2015

generic · Non-proprietary

Non-proprietary
generic
Tablets 25 micrograms
A3 · Amber 3 · No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Store in airtight and light resistant containers.
11th May 2015

Dixarit · Boehringer Ingelheim

Boehringer Ingelheim
Dixarit
Tablets s/c 25 micrograms
A3 · Amber 3 · No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Store in airtight and light resistant containers.
11th May 2015

Lactation Safety Information

For hypertension

For hypertension
Alternative appropriate antihypertensive
Moderate published evidence of safety
Moderate to significant amounts in breast milk
May interfere with lactation
Possible adverse reaction (unconfirmed, single case report) in a breastfed infant
Monitor infant for hypotension
15th January 2017

For migraine

For migraine
Propranolol/ Metoprolol
May interfere with lactation
Moderate level of published evidence of use in breastfeeding
For prophylaxis of migraine
Moderate to significant amounts in breast milk

New Medicines

Validive · Mucositis; radiotherapy-induced in head and neck cancer

Information

Validive
New formulation
BioAlliance Pharma
BioAlliance Pharma

Development and Regulatory status

Phase II Clinical Trials
Phase II Clinical Trials
Phase II Clinical Trials
Yes
Yes

Category

Agonist to imidazoline & alpha 2 adrenergic receptors, once-daily extended-release
Oral mucositis affects ~ 2 in 10,000 people in the EU (equivalent to around 101,000 people). Severe oral mucositis occurs in 60% of pts with head and neck cancer having radiotherapy & may induce intense oral pain and eating disability requiring artificial nutritional support. In 20 to 30% of cases, pts have to be hospitalised & the disease may result in modification or discontinuation of radiotherapy in more than 10% of them [3].
Mucositis; radiotherapy-induced in head and neck cancer
Buccal